Sotabase

Career

· Staff AI Scientist, Invitae2023–
· Researcher in Interactive Robotics Group, MIT Media Lab2015–
· Research Scientist, NASA2015–

Publications (66)

The landscape of kinase fusions in cancer
Nature Communications · 2014
872
cited
Precision Targeted Therapy with BLU-667 for RET-Driven Cancers.
Cancer Discovery · 2018
337
cited
First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway.
Cancer Discovery · 2015
264
cited
A precision therapy against cancers driven by KIT/PDGFRA mutations
Science Translational Medicine · 2017
175
cited
Design, synthesis, and evaluation of orally active benzimidazoles and benzoxazoles as vascular endothelial growth factor-2 receptor tyrosine kinase inhibitors.
Journal of Medicinal Chemistry · 2007
144
cited
Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.
Journal of Medicinal Chemistry · 2007
89
cited
Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline.
Journal of Medicinal Chemistry · 2009
88
cited
Acquired On-Target Clinical Resistance Validates FGFR4 as a Driver of Hepatocellular Carcinoma.
Cancer Discovery · 2019
75
cited
Selective and Potent Raf Inhibitors Paradoxically Stimulate Normal Cell Proliferation and Tumor Growth
Molecular Cancer Therapeutics · 2010
74
cited
Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.
Journal of Medicinal Chemistry · 2006
67
cited
Bayesian Inference of Linear Temporal Logic Specifications for Contrastive Explanations
International Joint Conference on Artificial Intelligence · 2019
62
cited
Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase.
Bioorganic & Medicinal Chemistry Letters · 2009
58
cited
Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity.
Journal of Medicinal Chemistry · 2008
56
cited
PHEE: A Dataset for Pharmacovigilance Event Extraction from Text
Conference on Empirical Methods in Natural Language Processing · 2022
54
cited
Conformation-specific effects of Raf kinase inhibitors.
Journal of Medicinal Chemistry · 2012
45
cited
Discovery of potent and highly selective thienopyridine Janus kinase 2 inhibitors.
Journal of Medicinal Chemistry · 2011
42
cited
Collaborative Planning with Encoding of Users' High-Level Strategies
AAAI Conference on Artificial Intelligence · 2017
41
cited
Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors.
Bioorganic & Medicinal Chemistry Letters · 2007
35
cited
Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.
Bioorganic & Medicinal Chemistry Letters · 2012
34
cited
Alkynylpyrimidine amide derivatives as potent, selective, and orally active inhibitors of Tie-2 kinase.
Journal of Medicinal Chemistry · 2007
27
cited
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Joseph Kim | Researcher Profile | Sotabase | Sotabase