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Researchers
Career
·
Co-founder
,
Drug-Discovery Startup
2022–
·
Postdoctoral Researcher
,
Broad Institute of MIT and Harvard
2019–2022
·
PhD in Computer Science
,
Stanford University
2013–2018
·
B.S. in EECS and B.A. in Applied Mathematics
,
UC Berkeley
2007–2011
Publications
(51)
Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA
Annals of Oncology · 2020
1,049
cited
M-CAP eliminates a majority of variants of uncertain significance in clinical exomes at high sensitivity
Nature Genetics · 2016
778
cited
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
Nature · 2021
665
cited
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
Nature Medicine · 2021
300
cited
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment
Nature Genetics · 2022
260
cited
Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
bioRxiv · 2020
256
cited
Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data
bioRxiv · 2021
169
cited
Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics
Nature Genetics · 2022
151
cited
Deriving genomic diagnoses without revealing patient genomes
Science · 2017
132
cited
Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity
Nature Genetics · 2022
128
cited
Cellular and inter-cellular rewiring of the human colon during ulcerative colitis
2019
96
cited
SAIGE-GENE+ improves the efficiency and accuracy of set-based rare variant association tests
Nature Genetics · 2022
92
cited
AMELIE speeds Mendelian diagnosis by matching patient phenotype and genotype to primary literature
Science Translational Medicine · 2020
90
cited
Severe autoinflammation in four patients with C-terminal variants in CDC42 successfully treated with IL-1β inhibition.
Journal of Allergy and Clinical Immunology · 2019
83
cited
S-CAP extends pathogenicity prediction to genetic variants that affect RNA splicing
Nature Genetics · 2019
52
cited
Phrank measures phenotype sets similarity to greatly improve Mendelian diagnostic disease prioritization
Genetics in Medicine · 2018
50
cited
A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2
bioRxiv · 2021
39
cited
Convolutional Neural Networks for Fashion Classification and Object Detection
2015
34
cited
Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatment
bioRxiv · 2020
34
cited
AMELIE accelerates Mendelian patient diagnosis directly from the primary literature
bioRxiv · 2017
27
cited
Show all 51 papers →
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Karthik Jagadeesh | Researcher Profile | Sotabase | Sotabase