Sotabase

Career

· Director of ML and AI, RWD, Natera2025–
· Sr. Director, Machine Learning, Seer2022–2025
· Principal Machine Learning Researcher, Seer2021–2022
· Manager, Computational Genomics, Ancestry2018–2021
· Senior Staff Computational Informatics Scientist, Ancestry2017–2018
· Staff Clinical Informatics Scientist, Ancestry2016–2017
· Research Scientist, Division of Medical Genetics, Pediatrics, Stanford University2014–2016
· Ph.D., Electrical Engineering (Computational), Stanford University2010–2014
· Research Intern, Massachusetts Institute of Technology2007–2007
· Intern, Cisco2006–2006
· Ancestry
· MS in Computer Science, University of California, Berkeley

Publications (49)

Mapping the human genetic architecture of COVID-19
Nature · 2021
804
cited
M-CAP eliminates a majority of variants of uncertain significance in clinical exomes at high sensitivity
Nature Genetics · 2016
778
cited
Systematic reanalysis of clinical exome data yields additional diagnoses: implications for providers
Genetics in Medicine · 2016
301
cited
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease
Nature Genetics · 2022
137
cited
Microbiota modulate transcription in the intestinal epithelium without remodeling the accessible chromatin landscape
Genome Research · 2014
132
cited
BioText Search Engine: beyond abstract search
Bioinform. · 2007
131
cited
Clustering of 770,000 genomes reveals post-colonial population structure of North America
Nature Communications · 2017
113
cited
Mutations of AKT3 are associated with a wide spectrum of developmental disorders including extreme megalencephaly
Brain : a journal of neurology · 2017
101
cited
Whole-genome sequencing reveals host factors underlying critical COVID-19
Nature · 2022
95
cited
AMELIE speeds Mendelian diagnosis by matching patient phenotype and genotype to primary literature
Science Translational Medicine · 2020
90
cited
A first update on mapping the human genetic architecture of COVID-19
Nature · 2022
81
cited
Computational methods to detect conserved non-genic elements in phylogenetically isolated genomes: application to zebrafish
Nucleic Acids Research · 2013
81
cited
AncestryDNA COVID-19 Host Genetic Study Identifies Three Novel Loci
medRxiv · 2020
65
cited
Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects
Nature Genetics · 2022
50
cited
Phrank measures phenotype sets similarity to greatly improve Mendelian diagnostic disease prioritization
Genetics in Medicine · 2018
50
cited
PRISM offers a comprehensive genomic approach to transcription factor function prediction
Genome Research · 2013
42
cited
Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements
Philosophical Transactions of the Royal Society B: Biological Sciences · 2013
38
cited
Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping
bioRxiv · 2023
36
cited
The Enhancer Landscape during Early Neocortical Development Reveals Patterns of Dense Regulation and Co-option
PLoS Genetics · 2013
34
cited
Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease
medRxiv · 2020
32
cited
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Harendra Guturu | Researcher Profile | Sotabase | Sotabase