Sotabase

Career

· Professor, University of California, Berkeley2017–
· Researcher, Microsoft Research2007–2017
· Member of the Steering Committee, Berkeley AI Research (BAIR) Lab
· Bachelor of Science in Physics and Computer Science, Queen's University
· Undergraduate Degrees (Physics and Computer Science), Queen's University
· PhD in Computer Science, University of Toronto

Publications (94)

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
Nature Biotechnology · 2015
3,763
cited
FaST linear mixed models for genome-wide association studies
Nature Methods · 2011
1,169
cited
Rethinking drug design in the artificial intelligence era
Nature reviews. Drug discovery · 2019
592
cited
Improved linear mixed models for genome-wide association studies
Nature Methods · 2012
394
cited
Statistical and Computational Methods for Comparative Proteomic Profiling Using Liquid Chromatography-Tandem Mass Spectrometry
Molecular & Cellular Proteomics · 2005
317
cited
Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs
Nature Biomedical Engineering · 2018
278
cited
Orthologous CRISPR-Cas9 enzymes for Combinatorial Genetic Screens
Nature Biotechnology · 2017
248
cited
Conditioning by adaptive sampling for robust design
International Conference on Machine Learning · 2019
224
cited
Epigenome-wide association studies without the need for cell-type composition
Nature Methods · 2014
219
cited
Predictive Models for Breast Cancer Susceptibility from Multiple Single Nucleotide Polymorphisms
Clinical Cancer Research · 2004
188
cited
Learning protein fitness models from evolutionary and assay-labeled data
Nature Biotechnology · 2022
183
cited
Additive Contribution of HLA Class I Alleles in the Immune Control of HIV-1 Infection
Journal of Virology · 2010
182
cited
A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control
eLife · 2013
174
cited
Correction for hidden confounders in the genetic analysis of gene expression
Proceedings of the National Academy of Sciences of the United States of America · 2010
165
cited
Gaussian Process Prior Variational Autoencoders
Neural Information Processing Systems · 2018
157
cited
Multiple Alignment of Continuous Time Series
Neural Information Processing Systems · 2004
157
cited
Widespread Impact of HLA Restriction on Immune Control and Escape Pathways of HIV-1
Journal of Virology · 2012
137
cited
Extensive HLA class I allele promiscuity among viral CTL epitopes
European Journal of Immunology · 2007
130
cited
Lymphovascular Invasion Is Associated With Poor Survival in Gastric Cancer: An Application of Gene-Expression and Tissue Array Techniques
Annals of Surgery · 2006
127
cited
Correlates of Protective Cellular Immunity Revealed by Analysis of Population-Level Immune Escape Pathways in HIV-1
Journal of Virology · 2012
121
cited
Sotabase