Manolis Kellis

Institute Member, Broad Institute of MIT and Harvard

125 h-index · 112.8K citations · 770 papers

Mechanistic basis of human disease using a combination of computational and experimental techniques. Developing methods for systematic discovery and characterization of functional elements in the human genomediscovery and validation of gene-regulatory circuitryusing epigenomic information for annotating regulatory regions and their activityand using comparative genomics for recognizing coding and non-coding regions of functional importance. Topics include variation and diseasegenome interpretationgene regulationepigenomicsand genome evolution.

Labs

Computational Biology Group · MIT

Collaborators

Career

· Institute Member, Broad Institute of MIT and Harvard2004–

· Professor of Computer Science and Computational Biology, Massachusetts Institute of Technology (MIT)2004–

· Postdoctoral Researcher, Massachusetts Institute of Technology (MIT)2003–2004

· Doctor of Philosophy (Ph.D.) in Computer Science, Massachusetts Institute of Technology (MIT)2000–2003

· Masters of Engineering (M.Eng.) in Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)1999–2000

· Research Intern, Xerox Palo Alto Research Center (PARC)1999–

· Research Intern, World Wide Web Consortium1996–

· Bachelor of Science (B.S.) in Computer Science and Engineering, Massachusetts Institute of Technology (MIT)1995–1999

Publications (770)

The Genotype-Tissue Expression (GTEx) project

Nature Genetics · 2013

8,238

cited

Integrative analysis of 111 reference human epigenomes

Nature · 2015

5,895

cited

GENCODE: The reference human genome annotation for The ENCODE Project

Genome Research · 2012

4,426

cited

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

Nature · 2009

4,127

cited

GENCODE reference annotation for the human and mouse genomes

Nucleic Acids Res. · 2018

2,645

cited

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Nature · 2005

2,613

cited

Histone modifications at human enhancers reflect global cell-type-specific gene expression

Nature · 2009

2,493

cited

Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila

Cell · 2007

2,464

cited

Transcriptional regulatory code of a eukaryotic genome

Nature · 2004

2,380

cited

ChromHMM: automating chromatin-state discovery and characterization

Nature Methods · 2012

2,334

cited

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

Nucleic Acids Res. · 2011

2,229

cited

Evolution of genes and genomes on the Drosophila phylogeny

Nature · 2007

2,077

cited

Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals

Nature · 2005

2,018

cited

Single-cell transcriptomic analysis of Alzheimer’s disease

Nature · 2019

1,962

cited

Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype

Nature · 2004

1,958

cited

Sequencing and comparison of yeast species to identify genes and regulatory elements

Nature · 2003

1,916

cited

The NIH Roadmap Epigenomics Mapping Consortium

Nature Biotechnology · 2010

1,855

cited

Expanded encyclopaedias of DNA elements in the human and mouse genomes

Nature · 2020

1,751

cited

Computer/law journal · 1966

1,712

cited

Wisdom of crowds for robust gene network inference

Nature Methods · 2012

1,679

cited

Sotabase