Sotabase

Career

· Professor Of Biochemistry Biophysics, Weill Cornell Medicine2025–
· Professor, Department Of Cellular Molecular Medicine, University of California San Diego2015–2025
· Professor, Section Of Molecular Biology, Division Of Biological Sciences, University of California San Diego2015–2025
· Associate Professor, Department Of Molecular And Cellular Biology, Harvard University2011–2015
· Assistant Professor, Harvard University2007–2011
· Postdoctoral Fellow, University of California, Berkeley2001–2007

Publications (113)

Tug-of-War in Motor Protein Ensembles Revealed with a Programmable DNA Origami Scaffold
Science · 2012
404
cited
Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor
Cell · 2012
254
cited
Mechanism and regulation of cytoplasmic dynein.
Annual Review of Cell and Developmental Biology · 2015
240
cited
Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction
Nature · 2020
181
cited
Structural Basis for Microtubule Binding and Release by Dynein
Science · 2012
170
cited
Molecular Architecture of the ATP-Dependent Chromatin-Remodeling Complex SWR1
Cell · 2013
146
cited
Structural Basis for Eukaryotic Transcription-Coupled DNA Repair Initiation
Nature · 2017
136
cited
COSMIC2: A Science Gateway for Cryo-Electron Microscopy Structure Determination
Practice and Experience in Advanced Research Computing · 2017
130
cited
Visualizing flexibility at molecular resolution: analysis of heterogeneity in single-particle electron microscopy reconstructions.
Annual Review of Biophysics and Biomolecular Structure · 2007
110
cited
Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms
Nature Structural &Molecular Biology · 2007
108
cited
Lis1 regulates dynein by sterically blocking its mechanochemical cycle
eLife · 2014
107
cited
The orthogonal tilt reconstruction method: an approach to generating single-class volumes with no missing cone for ab initio reconstruction of asymmetric particles.
Journal of Structural Biology · 2006
103
cited
Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method
Proceedings of the National Academy of Sciences of the United States of America · 2007
97
cited
Lis1 promotes the formation of activated cytoplasmic dynein-1 complexes
Nature Cell Biology · 2020
91
cited
Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex
Nature Structural &Molecular Biology · 2006
90
cited
Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein
Cell · 2017
85
cited
DNA transposition: From a black box to a color monitor
Cell · 1995
82
cited
A Model for the ?d Resolvase Synaptic Complex
2001
64
cited
A Dimeric Structure for Archaeal Box C/D Small Ribonucleoproteins
Science · 2009
62
cited
Neural Regulation of α‐Dystroglycan Biosynthesis and Glycosylation in Skeletal Muscle
2000
51
cited
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