Sotabase

Career

· Visiting Researcher, Imperial College London2024–
· Doctor of Philosophy, Imperial College London2019–2023
· Postdoctoral Researcher, Tongji University2019–2023
· Advanced computational methods for aeronautics, Imperial College London2017–2018
· Engineering - Visiting Student, University of Edinburgh2015–2015

Publications (43)

Non-ATG–initiated translation directed by microsatellite expansions
Proceedings of the National Academy of Sciences of the United States of America · 2010
844
cited
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia
Proceedings of the National Academy of Sciences of the United States of America · 2013
761
cited
Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8
Nature Genetics · 2006
425
cited
C9orf72 BAC Mouse Model with Motor Deficits and Neurodegenerative Features of ALS/FTD
Neuron · 2016
342
cited
Serine 776 of Ataxin-1 Is Critical for Polyglutamine-Induced Disease in SCA1 Transgenic Mice
Neuron · 2003
309
cited
RAN Translation in Huntington Disease
Neuron · 2015
300
cited
Recovery from Polyglutamine-Induced Neurodegeneration in Conditional SCA1 Transgenic Mice
Journal of Neuroscience · 2004
263
cited
The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo
Neurobiology of Disease · 2006
233
cited
RORα-Mediated Purkinje Cell Development Determines Disease Severity in Adult SCA1 Mice
Cell · 2006
223
cited
RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2
Neuron · 2017
122
cited
Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice
Proceedings of the National Academy of Sciences of the United States of America · 2020
114
cited
The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7
Proceedings of the National Academy of Sciences of the United States of America · 2008
89
cited
Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model
Neuron · 2019
83
cited
Targeted Deletion of a Single Sca8 Ataxia Locus Allele in Mice Causes Abnormal Gait, Progressive Loss of Motor Coordination, and Purkinje Cell Dendritic Deficits
Journal of Neuroscience · 2006
71
cited
Mutant β-III Spectrin Causes mGluR1α Mislocalization and Functional Deficits in a Mouse Model of Spinocerebellar Ataxia Type 5
Journal of Neuroscience · 2014
68
cited
SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F
EMBO Journal · 2018
64
cited
Hippocampal sclerosis dementia with the C9ORF72 hexanucleotide repeat expansion
Neurobiology of Aging · 2014
36
cited
Repeat-Associated Non-ATG Translation in Neurological Diseases.
Cold Spring Harbor Perspectives in Biology · 2018
36
cited
Survival and Motor Phenotypes in FVB C9-500 ALS/FTD BAC Transgenic Mice Reproduced by Multiple Labs
Neuron · 2020
31
cited
CCG•CGG interruptions in high‐penetrance SCA8 families increase RAN translation and protein toxicity
bioRxiv · 2021
27
cited
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Taihang Zu | Researcher Profile | Sotabase | Sotabase