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Career

· Doctoral Research Scholar (Ph.D.), National Institute of Technology, Tiruchirappalli2016–
· Ad Hoc Faculty, National Institute of Technology, Tiruchirappalli2013–2016
· Associate Head Of The Department (Mechanical Engineering), Sudharsan Engineering College2012–2013
· Assistant Professor (Mechanical Engineering), Mookambigai College of Engineering2010–2012
· Head Of Department And Manager, Mount Zion College of Engineering and Technology2008–2010

Publications (67)

The use of spirocyclic scaffolds in drug discovery.
Bioorganic & Medicinal Chemistry Letters · 2014
722
cited
FAST TCP: from theory to experiments
IEEE Network · 2005
235
cited
The Grid2003 production grid: principles and practice
Proceedings. 13th IEEE International Symposium on High performance Distributed Computing, 2004. · 2004
154
cited
Toxoplasma gondii Cyclic GMP-Dependent Kinase: Chemotherapeutic Targeting of an Essential Parasite Protein Kinase
Eukaryotic Cell · 2002
139
cited
A model for predicting likely sites of CYP3A4-mediated metabolism on drug-like molecules.
Journal of Medicinal Chemistry · 2003
125
cited
Hematopoietic Progenitor Kinase 1 Associates Physically and Functionally with the Adaptor Proteins B Cell Linker Protein and SLP-76 in Lymphocytes*
Journal of Biological Chemistry · 2001
121
cited
Structure-based design of β-site APP cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease.
Journal of Medicinal Chemistry · 2013
120
cited
Protocols for Bridging the Peptide to Nonpeptide Gap in Topological Similarity Searches
Journal of chemical information and computer sciences · 2001
108
cited
Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity.
Biochemistry · 2004
102
cited
SAR of 3,4-dihydropyrido[3,2-d]pyrimidone p38 inhibitors.
Bioorganic & Medicinal Chemistry Letters · 2003
99
cited
Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.
Bioorganic & Medicinal Chemistry Letters · 2003
76
cited
Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin.
Bioorganic & Medicinal Chemistry Letters · 2007
70
cited
Structure and Stereochemistry of Rediocide A, A Highly Modified Daphnane from Trigonostemon reidioides Exhibiting Potent Insecticidal Activity
2000
48
cited
Conformational control in structure-based drug design.
Bioorganic & Medicinal Chemistry Letters · 2017
47
cited
The medicinal chemistry of liver X receptor (LXR) modulators.
Journal of Medicinal Chemistry · 2014
46
cited
Liver X receptor
2013
42
cited
Selective Inhibition of Dog Hepatic CYP2B11 and CYP3A12
Journal of Pharmacology and Experimental Therapeutics · 2005
40
cited
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Bioorganic & Medicinal Chemistry Letters · 2007
39
cited
Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase type 1.
Journal of Medicinal Chemistry · 2011
39
cited
Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors.
Bioorganic & Medicinal Chemistry Letters · 2008
37
cited
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