Sotabase

Career

· Associate Director / Senior Principal Scientist, CADD, Novartis2025–
· Senior Research Scientist, Bristol Myers Squibb2023–2025
· Senior Research Scientist, Bristol Myers Squibb2022–2023
· Senior Scientist II, Merck2021–2022
· Postdoctoral Researcher, Stanford University2016–2019
· Research Assistant, UC Irvine2011–2016
· PhD in Biological Sciences, University of California, Irvine2011–2016
· Research Analyst II, Oregon Department of Human Services2010–2011
· Research Assistant, Oregon State University2009–2010
· BS in Biochemistry and Biophysics, Oregon State University2006–2010

Publications (39)

Molecular Dynamics Simulation for All
Neuron · 2018
2,253
cited
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex
Cell · 2019
363
cited
A fresh look at the Ramachandran plot and the occurrence of standard structures in proteins
Biomolecular Concepts · 2010
351
cited
How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling
Cell · 2020
128
cited
Structure and mechanism of the cation–chloride cotransporter NKCC1
Nature · 2019
96
cited
Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation
Nature Communications · 2021
89
cited
Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs
Nature Communications · 2019
69
cited
Gi- and Gs-coupled GPCRs show different modes of G-protein binding
Proceedings of the National Academy of Sciences of the United States of America · 2018
69
cited
Conformational selectivity in cytochrome P450 redox partner interactions
Proceedings of the National Academy of Sciences of the United States of America · 2016
56
cited
Uncovering patterns of atomic interactions in static and dynamic structures of proteins
bioRxiv · 2019
46
cited
On the occurrence of linear groups in proteins
Protein Science · 2009
44
cited
Leveraging nonstructural data to predict structures and affinities of protein–ligand complexes
Proceedings of the National Academy of Sciences of the United States of America · 2021
25
cited
Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists
Nature Communications · 2021
24
cited
Crystal Structure of Cindoxin, the P450cin Redox Partner
Biochemistry · 2014
21
cited
Delineating the Ligand–Receptor Interactions That Lead to Biased Signaling at the μ-Opioid Receptor
Journal of Chemical Information and Modeling · 2021
21
cited
Elucidating nitric oxide synthase domain interactions by molecular dynamics
Protein Science · 2015
20
cited
Molecular dynamics of the P450cam–Pdx complex reveals complex stability and novel interface contacts
Protein Science · 2015
20
cited
Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors
Journal of Medicinal Chemistry · 2014
19
cited
P450cin active site water: implications for substrate binding and solvent accessibility.
Biochemistry · 2013
13
cited
"Bind and Crawl" Association Mechanism of Leishmania major Peroxidase and Cytochrome c Revealed by Brownian and Molecular Dynamics Simulations.
Biochemistry · 2015
10
cited
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Scott Hollingsworth | Researcher Profile | Sotabase | Sotabase