Sotabase

Career

· Senior Scientific Director, Healthcare Consultancy Group - HCG2025–
· Scientific Director, Healthcare Consultancy Group - HCG2024–2025
· Scientific Director, ProEd Communications2023–2024
· Associate Scientific Director, ProEd Communications2022–2023
· Assistant Scientific Director, ProEd Communications2021–2022
· Clinical Research Manager, Department Of Obstetrics And Gynaecology, Mount Sinai Hospital (Toronto), Sinai Health System2019–2021
· Scientific Medical Writer, Mount Sinai Hospital (Toronto), Sinai Health System2017–2019
· Freelance Medical Writer, SCRIPT Medical2016–2017
· Manager, Zebrafish Core Facility, The Hospital for Sick Children2014–2017
· Research Associate, Hospital for Sick Children2010–2014
· Postdoctoral Fellow, Huntsman Cancer Institute2006–2010

Publications (25)

Interaction between the CD8 Coreceptor and Major Histocompatibility Complex Class I Stabilizes T Cell Receptor-Antigen Complexes at the Cell Surface*
Journal of Biological Chemistry · 2005
205
cited
Allelic variation in normal human FBN1 expression in a family with Marfan syndrome: a potential modifier of phenotype?
Human Molecular Genetics · 2003
133
cited
The CD8 T Cell Coreceptor Exhibits Disproportionate Biological Activity at Extremely Low Binding Affinities*
Journal of Biological Chemistry · 2003
111
cited
A Dominant Role for the Immunoproteasome in CD8+ T Cell Responses to Murine Cytomegalovirus
PLoS ONE · 2011
88
cited
Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region
European Journal of Immunology · 2007
84
cited
Recognition of nonpeptide antigens by human Vγ9Vδ2 T cells requires contact with cells of human origin
2004
71
cited
Anti-CD8 Antibodies Can Inhibit or Enhance Peptide-MHC Class I (pMHCI) Multimer Binding: This Is Paralleled by Their Effects on CTL Activation and Occurs in the Absence of an Interaction between pMHCI and CD8 on the Cell Surface 1
Journal of Immunology · 2003
65
cited
Twelve novel FBN1 mutations in Marfan syndrome and Marfan related phenotypes test the feasibility of FBN1 mutation testing in clinical practice
Journal of Medical Genetics · 2002
55
cited
Fibrillin-1 Misfolding and Disease
Antioxidants and Redox Signaling · 2006
46
cited
Ca2+ Release from the Endoplasmic Reticulum of NY-ESO-1–Specific T Cells Is Modulated by the Affinity of TCR and by the Use of the CD8 Coreceptor
Journal of Immunology · 2010
41
cited
Recognition of nonpeptide antigens by human V gamma 9V delta 2 T cells requires contact with cells of human origin.
Clinical and Experimental Immunology · 2004
32
cited
Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor
European Journal of Immunology · 2007
26
cited
Molecular effects of homocysteine on cbEGF domain structure: insights into the pathogenesis of homocystinuria.
Journal of Molecular Biology · 2005
25
cited
Novel CD8+ T Cell Antagonists Based on β2-Microglobulin*
Journal of Biological Chemistry · 2002
20
cited
Molecular analysis of eight mutations in FBN1
Human Genetics · 1999
14
cited
Marfan syndrome caused by a mutation in FBN1 that gives rise to cryptic splicing and a 33 nucleotide insertion in the coding sequence
Human Genetics · 2001
11
cited
Novel CD8+ T cell antagonists based on beta 2-microglobulin.
Journal of Biological Chemistry · 2002
2
cited
and CD8 on the Cell Surface Absence of an Interaction between pMHCI on CTL Activation and Occurs in the Binding: This Is Paralleled by Their Effects Peptide-MHC Class I (pMHCI) Multimer Anti-CD8 Antibodies Can Inhibit or Enhance
2013
CD8 on the Cell Surface and of an Interaction between pMHCI Activation and Occurs in the Absence Paralleled by Their Effects on CTL (pMHCI) Multimer Binding: This Is Enhance Peptide-MHC Class I Anti-CD8 Antibodies Can Inhibit or
2010
Cell Surface Absence of an Interaction between pMHCI on CTL Activation and Occurs in the Binding : This Is Paralleled by Their Effects Peptide-MHC Class I ( pMHCI ) Multimer Anti-CD 8 Antibodies Can Inhibit or Enhance
2003
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Sarah Hutchinson | Researcher Profile | Sotabase | Sotabase