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Career

· Professor, Acadia University2001–
· Doctor of Philosophy (PhD), English, Penn State University1994–2000
· Master of Arts (M.A.), English, U of Alberta

Publications (91)

Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.
EMBO Journal · 1995
448
cited
Structure and function of the multifunctional DNA-repair enzyme exonuclease III
Nature · 1995
358
cited
Purified Escherichia coli recA protein catalyzes homologous pairing of superhelical DNA and single-stranded fragments.
Proceedings of the National Academy of Sciences of the United States of America · 1979
277
cited
Structure of the DNA Repair Enzyme Endonuclease IV and Its DNA Complex Double-Nucleotide Flipping at Abasic Sites and Three-Metal-Ion Catalysis
Cell · 1999
273
cited
Atomic structure of the DNA repair [4Fe-4S] enzyme endonuclease III.
Science · 1992
269
cited
Endonuclease III (nth) mutants of Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America · 1985
175
cited
Homologous pairing in genetic recombination: recA protein makes joint molecules of gapped circular DNA and closed circular DNA
Cell · 1980
153
cited
Homologous pairing in genetic recombination: complexes of recA protein and DNA.
Proceedings of the National Academy of Sciences of the United States of America · 1979
134
cited
Cloning and Expression of the cDNA Encoding the Human Homologue of the DNA Repair Enzyme, Escherichia coli Endonuclease III*
Journal of Biological Chemistry · 1997
133
cited
Stimulation of Human Endonuclease III by Y Box-binding Protein 1 (DNA-binding Protein B)
Journal of Biological Chemistry · 2001
130
cited
Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA
Proceedings of the National Academy of Sciences of the United States of America · 2012
128
cited
Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1
Nature Structural Biology · 1995
126
cited
Single strands induce recA protein to unwind duplex DNA for homologous pairing
Nature · 1979
114
cited
Substrate Specificity of Human Endonuclease III (hNTH1)
Journal of Biological Chemistry · 2003
110
cited
A highly conserved endonuclease activity present in Escherichia coli, bovine, and human cells recognizes oxidative DNA damage at sites of pyrimidines
Molecular and Cellular Biology · 1987
106
cited
Polarity of heteroduplex formation promoted by Escherichia coli recA protein.
Proceedings of the National Academy of Sciences of the United States of America · 1981
105
cited
DNA apurinic-apyrimidinic site binding and excision by endonuclease IV
Nature Structural &Molecular Biology · 2008
101
cited
Targeted Deletion of mNth1 Reveals a Novel DNA Repair Enzyme Activity
Molecular and Cellular Biology · 2002
100
cited
UV-induced pyrimidine hydrates in DNA are repaired by bacterial and mammalian DNA glycosylase activities.
Biochemistry · 1989
100
cited
The topology of homologous pairing promoted by RecA protein
Cell · 1980
94
cited
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