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Career

· DPhil Candidate @ University of Oxford, University of Oxford2023–

Publications (106)

Most F508del-CFTR Is Targeted to Degradation at an Early Folding Checkpoint and Independently of Calnexin
Molecular and Cellular Biology · 2005
207
cited
Revertants, low temperature, and correctors reveal the mechanism of F508del-CFTR rescue by VX-809 and suggest multiple agents for full correction.
Chemistry and Biology · 2013
177
cited
The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hsp70.
Biochemical Journal · 2002
149
cited
Cystic Fibrosis F508del Patients Have Apically Localized CFTR in a Reduced Number of Airway Cells
Laboratory Investigation · 2000
120
cited
From the endoplasmic reticulum to the plasma membrane: mechanisms of CFTR folding and trafficking
Cellular and Molecular Life Sciences · 2016
103
cited
Rescuing mutant CFTR: a multi-task approach to a better outcome in treating cystic fibrosis.
Current pharmaceutical design · 2013
95
cited
Control of cystic fibrosis transmembrane conductance regulator membrane trafficking: not just from the endoplasmic reticulum to the Golgi
The FEBS Journal · 2013
93
cited
Solubilizing mutations used to crystallize one CFTR domain attenuate the trafficking and channel defects caused by the major cystic fibrosis mutation.
Chemistry and Biology · 2008
88
cited
Cystic fibrosis patients with the 3272‐26A→G mutation have mild disease, leaky alternative mRNA splicing, and CFTR protein at the cell membrane
Human Mutation · 1999
75
cited
Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis
EBioMedicine · 2014
75
cited
Biochemical methods to assess CFTR expression and membrane localization.
Journal of Cystic Fibrosis · 2004
64
cited
EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1
Journal of Cell Science · 2016
58
cited
The effect of using sanitary ware as aggregates on rendering mortars' performance
2016
47
cited
Contribution of Casein Kinase 2 and Spleen Tyrosine Kinase to CFTR Trafficking and Protein Kinase A-Induced Activity
Molecular and Cellular Biology · 2011
45
cited
Methods for RNA extraction, cDNA preparation and analysis of CFTR transcripts.
Journal of Cystic Fibrosis · 2004
44
cited
Increased efficacy of VX-809 in different cellular systems results from an early stabilization effect of F508del-CFTR
Pharmacology Research & Perspectives · 2015
43
cited
Deletion of CFTR Translation Start Site Reveals Functional Isoforms of the Protein in CF Patients
Cellular Physiology and Biochemistry · 2009
42
cited
Antagonistic Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Cell Surface Expression by Protein Kinases WNK4 and Spleen Tyrosine Kinase
Molecular and Cellular Biology · 2011
41
cited
LMTK2-mediated Phosphorylation Regulates CFTR Endocytosis in Human Airway Epithelial Cells*
Journal of Biological Chemistry · 2014
41
cited
Regulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity
Frontiers in Chemistry · 2016
39
cited
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Miguel Farinha | Researcher Profile | Sotabase | Sotabase