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Career

· Director, MIT Julia Lab
· Research Scientist, MIT Julia Lab

Publications (38)

Identification of angiotensin II receptor subtypes.
Biochemical and Biophysical Research Communications - BBRC · 1989
848
cited
Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor
Molecular Cancer Therapeutics · 2005
196
cited
Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.
Journal of Medicinal Chemistry · 2007
166
cited
Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors.
Journal of Medicinal Chemistry · 2005
137
cited
Trifluoromethyl ketones as inhibitors of histone deacetylase.
Bioorganic & Medicinal Chemistry Letters · 2002
132
cited
Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC).
Bioorganic & Medicinal Chemistry Letters · 2002
95
cited
ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia.
Blood · 2007
79
cited
Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors
Molecular Cancer Therapeutics · 2006
64
cited
α-Keto amides as inhibitors of histone deacetylase
2003
64
cited
Differential protein acetylation induced by novel histone deacetylase inhibitors.
Biochemical and Biophysical Research Communications - BBRC · 2004
62
cited
Discovery of selective hydroxamic acid inhibitors of tumor necrosis factor-α converting enzyme
2001
46
cited
7-Aminopyrazolo[1,5-a]pyrimidines as potent multitargeted receptor tyrosine kinase inhibitors.
Journal of Medicinal Chemistry · 2008
44
cited
A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units.
Bioorganic & Medicinal Chemistry Letters · 2003
43
cited
Indole amide hydroxamic acids as potent inhibitors of histone deacetylases.
Bioorganic & Medicinal Chemistry Letters · 2003
38
cited
Thienopyridine urea inhibitors of KDR kinase.
Bioorganic & Medicinal Chemistry Letters · 2007
38
cited
Heterocyclic ketones as inhibitors of histone deacetylase.
Bioorganic & Medicinal Chemistry Letters · 2003
37
cited
Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors.
Bioorganic & Medicinal Chemistry Letters · 2008
34
cited
3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.
Journal of Medicinal Chemistry · 2008
29
cited
Isoindolinone ureas: a novel class of KDR kinase inhibitors.
Bioorganic & Medicinal Chemistry Letters · 2004
27
cited
Preclinical Characterization of ABT-348, a Kinase Inhibitor Targeting the Aurora, Vascular Endothelial Growth Factor Receptor/Platelet-Derived Growth Factor Receptor, and Src Kinase Families
Journal of Pharmacology and Experimental Therapeutics · 2012
25
cited
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