Sotabase

Career

· Professor of Chemistry and Biochemistry, University of Delaware1996–
· Postdoctoral Researcher, American Cancer Society1994–1996
· PhD Student, Columbia University1994–
· Postdoctoral Researcher, University of California Berkeley1994–1996
· MS in Computer Science, Columbia University1990–
· Bachelor's degree, West Chester University1989–

Publications (43)

Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore
Cell · 2018
164
cited
A Structure-Based Library Approach to Kinase Inhibitors
1996
102
cited
Light activated recombination.
Journal of the American Chemical Society · 2005
63
cited
Structure-based design of selective agonists for a rickets-associated mutant of the vitamin d receptor.
Journal of the American Chemical Society · 2002
56
cited
Light‐Activated Transcription and Repression by Using Photocaged SERMs
ChemBioChem · 2004
47
cited
Circumventing anti-androgen resistance by molecular design.
Journal of the American Chemical Society · 2007
38
cited
Automated time-lapse microscopy and high-resolution tracking of cell migration
Cytotechnology (Dordrecht) · 2006
36
cited
Engineering selectivity and discrimination into ligand-receptor interfaces.
Chemistry and Biology · 2002
36
cited
Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents.
Chemico-Biological Interactions · 2016
35
cited
Geometric Control of a Pyridoxal-Catalyzed Aldol Condensation
1994
34
cited
Light-activated gene expression directs segregation of co-cultured cells in vitro.
ACS Chemical Biology · 2010
34
cited
Photocaged DNA Provides New Levels of Transcription Control
ChemBioChem · 2012
28
cited
Chemical biology of steroid and nuclear hormone receptors.
Current Opinion in Chemical Biology · 2007
23
cited
Functionally orthogonal ligand-receptor pairs for the selective regulation of gene expression generated by manipulation of charged residues at the ligand-receptor interface of ER alpha and ER beta.
Journal of the American Chemical Society · 2002
23
cited
Design and synthesis of complementing ligands for mutant thyroid hormone receptor TRβ(R320H): a tailor-made approach toward the treatment of resistance to thyroid hormone
2005
21
cited
Photo-caged agonists of the nuclear receptors RARgamma and TRbeta provide unique time-dependent gene expression profiles for light-activated gene patterning.
Bioorganic & Medicinal Chemistry · 2004
19
cited
Selective chemical rescue of a thyroid-hormone-receptor mutant, TRbeta(H435Y), identified in pituitary carcinoma and resistance to thyroid hormone.
Angewandte Chemie · 2008
19
cited
The new biomimetic chemistry: artificial transcription factors.
ACS Chemical Biology · 2007
18
cited
Rational design of vitamin D3 analogues which selectively restore activity to a vitamin D receptor mutant associated with rickets.
Organic Letters · 2002
17
cited
Selective regulation of gene expression using rationally-modified retinoic acid receptors [16]
1999
17
cited
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