Sotabase

Career

· Young Investigator, Climate Modeling, Ai22024–
· PhD in Biostatistics, University of California, Berkeley2019–2024
· Student (Statistics MA), UC Berkeley Department of Statistics2017–2019

Publications (53)

Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
Cell · 2012
718
cited
Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2.
Biochimica et Biophysica Acta · 2008
328
cited
Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains.
Cell Reports · 2015
283
cited
Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer.
Cell Reports · 2016
180
cited
Combined PI3K/mTOR and MEK Inhibition Provides Broad Antitumor Activity in Faithful Murine Cancer Models
Clinical Cancer Research · 2012
136
cited
A Peptide-Based Target Screen Implicates the Protein Kinase CK2 in the Global Regulation of Caspase Signaling
Science Signaling · 2011
96
cited
An Unbiased Evaluation of CK2 Inhibitors by Chemoproteomics
Molecular & Cellular Proteomics · 2008
93
cited
Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2.
Biochimica et Biophysica Acta · 2005
93
cited
Regulation of cell proliferation and survival: convergence of protein kinases and caspases.
Biochimica et Biophysica Acta · 2010
85
cited
The dynamic nature of the kinome.
Biochemical Journal · 2013
82
cited
Peptide biosensors for the electrochemical measurement of protein kinase activity.
Analytical Chemistry · 2008
80
cited
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells
Science Signaling · 2022
76
cited
Protein kinase CK2 is a constitutively active enzyme that promotes cell survival: strategies to identify CK2 substrates and manipulate its activity in mammalian cells.
Methods in Enzymology · 2010
74
cited
Regulation of caspase pathways by protein kinase CK2: identification of proteins with overlapping CK2 and caspase consensus motifs
Molecular and Cellular Biochemistry · 2011
35
cited
Unbiased Functional Proteomics Strategy for Protein Kinase Inhibitor Validation and Identification of bona fide Protein Kinase Substrates: Application to Identification of EEF1D as a Substrate for CK2
Journal of Proteome Research · 2011
35
cited
A Novel HSP90 Inhibitor–Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer
Clinical Cancer Research · 2016
30
cited
PPP2R2A prostate cancer haploinsufficiency is associated with worse prognosis and a high vulnerability to B55α/PP2A reconstitution that triggers centrosome destabilization
Oncogenesis · 2019
27
cited
NetrinG1+ Cancer-Associated Fibroblasts Generate Unique Extracellular Vesicles that Support the Survival of Pancreatic Cancer Cells Under Nutritional Stress
bioRxiv · 2021
26
cited
Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma
Science Signaling · 2020
24
cited
Intrinsic Resistance to MEK Inhibition through BET Protein–Mediated Kinome Reprogramming in NF1-Deficient Ovarian Cancer
Molecular Cancer Research · 2019
23
cited
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