Sotabase

Career

· Software Engineer, Massachusetts Institute of Technology2024–
· Undergraduate Research and Innovation Scholar, MIT Julia Lab2017–

Publications (24)

Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan.
Cell Reports · 2019
83
cited
Quantification of measurable residual disease using duplex sequencing in adults with acute myeloid leukemia
Haematologica · 2023
25
cited
Ultra-accurate Duplex Sequencing for the assessment of pretreatment ABL1 kinase domain mutations in Ph+ ALL
Blood Cancer Journal · 2020
21
cited
Adopting Duplex Sequencing™ Technology for Genetic Toxicity Testing: A Proof-of-Concept Mutagenesis Experiment with N-Ethyl-N-Nitrosourea (ENU)-Exposed Rats
bioRxiv · 2023
12
cited
Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis · 2023
9
cited
svCapture: efficient and specific detection of very low frequency structural variant junctions by error-minimized capture sequencing
bioRxiv · 2022
4
cited
Ultra-Accurate Assessment of Pretreatment ABL1 Kinase Domain (KD) Mutations in Patients (pts) with Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL) Using Duplex Sequencing (DS)
Blood · 2019
2
cited
Characterization of Clonal Dynamics after Hematopoietic Cell Transplantation Using Ultra-Sensitive Duplex Sequencing
Blood · 2019
1
cited
Duplex Sequencing Accurately Detects Variants below 1/100,000 in Genes Recurrently Mutated in Acute Myeloid Leukemia
Blood · 2018
1
cited
Duplex Sequencing for Ultra-Low Frequency Measurable Residual Disease Detection in Adult Acute Myeloid Leukemia
Blood · 2021
1
cited
Redefining "Gold Standard": Ultra-Sensitive Characterization of Commercial DNA Standards with Duplex Sequencing
Blood · 2019
1
cited
Abstract 422: Duplex sequencing for MRD detection in acute myeloid leukemia
Clinical research · 2019
Abstract 4649: Duplex Sequencing detects rare subclonal variants that mark early carcinogenesis and preneoplastic clonal evolution
Tumor Biology · 2019
Abstract A008: TP53 field defects in uterine fluid are associated with ovarian cancer risk
Cancer Research · 2022
Abstract A009: Longitudinal monitoring of pediatric acute myeloid leukemia using duplex sequencing of patient-specific panels reveals ultra-low frequency MRD that marks persistent carcinogenesis and complex clonal evolution
Cancer Research · 2022
Abstract LB063: Duplex Sequencing reveals ubiquitous clonal hematopoiesis and complex donor-recipient clonal dynamics following HSCT
Cancer Research · 2022
Abstract LB254: Accurate detection of low frequency AML-associated mutations in vitro using Duplex Sequencing with enzymatic fragmentation
Cancer Research · 2023
Abstract PR005: TP53 field defects in uterine fluid are associated with ovarian cancer risk
Cancer Research · 2022
Abstract PR04: Clonal landscapes of hematologic malignancies redefined by ultrasensitive duplex sequencing
Oral Presentations - Proffered Abstracts · 2020
Analytical Validation of a Duplex Sequencing AML Assay with a Limit of Detection Below 0.01% VAF for SNVs and Indels
Blood · 2023
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Jacob Higgins | Researcher Profile | Sotabase | Sotabase