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Career

· Systems Programmer, Intel2021–
· Computational Biology Intern at Spencer Labs, Washington University at St. Louis2021–
· Graduate Teaching Assistant and Researcher, Missouri University of Science and Technology2019–
· Cybersecurity and AI Researcher, Sandia National Laboratories

Publications (96)

Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.
Journal of Medicinal Chemistry · 2005
144
cited
Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis.
Bioorganic & Medicinal Chemistry · 1999
138
cited
Two synthetic approaches to rebeccamycin
1985
82
cited
Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.
Journal of Medicinal Chemistry · 2014
75
cited
Synthesis and antitumor evaluation of water soluble taxol phosphates
1993
72
cited
(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine.
Journal of Medicinal Chemistry · 2003
58
cited
Synthesis of the Core Trisaccharide of Esperamicin: Corroboration of the Proposed Structure for Its Rearrangement Product and Stabilization of the Core Trisaccharide Domain.
1991
56
cited
An effective procedure for the acylation of azaindoles at C-3.
Journal of Organic Chemistry · 2002
48
cited
A strategy to minimize reactive metabolite formation: discovery of (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a potent, orally bioavailable corticotropin-releasing factor-1 receptor antagonist.
Journal of Medicinal Chemistry · 2009
48
cited
Sordarin oxazepine derivatives as potent antifungal agents.
Bioorganic & Medicinal Chemistry Letters · 2002
45
cited
Bicyclic and tricyclic analogues of anthramycin.
Journal of Medicinal Chemistry · 1985
43
cited
REGIOSPECIFIC FUNCTIONALIZATION OF 1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE AND STRUCTURALLY RELATED CYCLIC UREA DERIVATIVES
1995
42
cited
(+)-Dinapsoline: an efficient synthesis and pharmacological profile of a novel dopamine agonist.
Journal of Medicinal Chemistry · 2002
37
cited
Studies toward structure-activity relationships of taxol®: synthesis and cytotoxicity of taxol® analogues with C-2′ modified phenylisoserine side chains☆
1993
35
cited
Total synthesis of (±) podophyllotoxin
1987
35
cited
Synthesis and antitumor evaluation of paclitaxel phosphonooxymethyl ethers: a novel class of water soluble paclitaxel pro-drugs
1996
34
cited
A new and mild method for the reduction of secondary amides to carbinolamine ethers and imines: a conversion of oxotomaymycin to tomaymycin
1984
32
cited
A synthesis of N-bridged 5,6-bicylic pyridines via a mild cyclodehydration using the burgess reagent and discovery of a novel carbamylsulfonylation reaction.
Organic Letters · 2008
32
cited
Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11.
Journal of Medicinal Chemistry · 2005
31
cited
New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.
Bioorganic & Medicinal Chemistry Letters · 2007
31
cited
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