Sotabase

Career

· MS EE, Stanford University1999–2001
· Cadet, 42 Silicon Valley
· Experience, Adobe
· Experience, Bristol Myers Squibb
· PhD in Chemistry, Caltech
· Education, Harvard University
· Education, Huazhong University of Science and Technology
· Consultant, Hyperion
· Experience, MachinaMinds
· Experience, Marketo
· Experience, Molecular Foundry
· Experience, Oracle
· Vice President of Foundry Operations and Yield Engineering, Renesas Electronics
· Education, Stanford University
· Former Data Analyst, Stanford University
· Visiting Researcher, Stanford University
· Visiting Scholar, Stanford University
· CEO, Tigon Advisory Corp.

Publications (51)

Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair
Proceedings of the National Academy of Sciences of the United States of America · 2013
351
cited
Clinical targeting of HIV capsid protein with a long-acting small molecule
Nature · 2020
301
cited
Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing
PLoS Pathogens · 2014
277
cited
The Ubiquitin Carboxyl Hydrolase BAP1 Forms a Ternary Complex with YY1 and HCF-1 and Is a Critical Regulator of Gene Expression
Molecular and Cellular Biology · 2010
270
cited
Identifying off-target effects and hidden phenotypes of drugs in human cells
Nature Chemical Biology · 2006
250
cited
Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile
Antimicrobial Agents and Chemotherapy · 2016
233
cited
DNA Unwinding Is the Primary Determinant of CRISPR-Cas9 Activity.
Cell Reports · 2018
185
cited
Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.
Cell Reports · 2019
177
cited
A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes
PLoS Pathogens · 2016
148
cited
A role for mammalian Ubc6 homologues in ER-associated protein degradation.
Journal of Cell Science · 2002
132
cited
A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model
Nature Medicine · 2019
123
cited
Identification and Characterization of ZapC, a Stabilizer of the FtsZ Ring in Escherichia coli
Journal of Bacteriology · 2011
123
cited
The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer*♦
Journal of Biological Chemistry · 2015
119
cited
Roles of ubiquitin signaling in transcription regulation.
Cellular Signalling · 2012
98
cited
Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway
Proceedings of the National Academy of Sciences of the United States of America · 2011
95
cited
Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag
Journal of the American Chemical Society · 2011
88
cited
Engineered CRISPR/Cas9 enzymes improve discrimination by slowing DNA cleavage to allow release of off-target DNA
Nature Communications · 2020
79
cited
A Role for CHH Methylation in the Parent-of-Origin Effect on Altered Circadian Rhythms and Biomass Heterosis in Arabidopsis Intraspecific Hybrids[W][OPEN]
The Plant Cell · 2014
75
cited
Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus
Antimicrobial Agents and Chemotherapy · 2015
70
cited
Discovery of GS-9688 (Selgantolimod), as a Potent and Selective Oral Toll-like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.
Journal of Medicinal Chemistry · 2020
67
cited
Sotabase
Helen Yu | Researcher Profile | Sotabase | Sotabase