Sotabase

Career

· Fractional AI Executive Advisor, Gestalt AI (Current)2025–
· Advisory Board Member, Georgia Institute of Technology2023–
· Chief AI Data Science Officer, hC Bioscience, Inc.2021–2025
· Bioinformatics Advisor, Center For Systems Immunology, Benaroya Research Institute at Virginia Mason2020–2022
· Founder, Strategic Consultant, Gestalt Strategies, Inc2019–2022
· Director, Precision Medicine, ImmusanT, Inc.2015–2019
· Research Fellow, Massachusetts General Hospital2009–2017

Publications (83)

Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Nature · 2013
3,300
cited
Thinking fast and slow: Optimization decomposition across timescales
IEEE Conference on Decision and Control · 2017
3,067
cited
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
Cell Metabolism · 2015
937
cited
Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma
Cell Host and Microbe · 2012
243
cited
Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.
Gastroenterology · 2013
232
cited
Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis
PLoS Genetics · 2013
203
cited
Mechanisms of Pediatric Inflammatory Bowel Disease.
Annual Review of Immunology · 2016
133
cited
Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies.
The Lancet Gastroenterology and Hepatology · 2017
124
cited
Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.
Immunity · 2016
123
cited
Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease
Science Advances · 2019
112
cited
RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy.
Cell Reports · 2016
93
cited
The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells
eLife · 2015
91
cited
Smoothed Online Convex Optimization in High Dimensions via Online Balanced Descent
Annual Conference Computational Learning Theory · 2018
86
cited
Concomitant BRAF and PI3K/mTOR Blockade Is Required for Effective Treatment of BRAFV600E Colorectal Cancer
Clinical Cancer Research · 2013
84
cited
An Online Algorithm for Smoothed Regression and LQR Control
International Conference on Artificial Intelligence and Statistics · 2018
79
cited
Beyond Online Balanced Descent: An Optimal Algorithm for Smoothed Online Optimization
Neural Information Processing Systems · 2019
73
cited
Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics
Proceedings of the National Academy of Sciences of the United States of America · 2015
69
cited
Elevated serum interleukin‐2 after gluten correlates with symptoms and is a potential diagnostic biomarker for coeliac disease
Alimentary Pharmacology and Therapeutics · 2019
68
cited
Essential Cell-Autonomous Role for Interferon (IFN) Regulatory Factor 1 in IFN-γ-Mediated Inhibition of Norovirus Replication in Macrophages
Journal of Virology · 2012
64
cited
Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules.
ACS Chemical Biology · 2013
62
cited
Sotabase
Gautam Goel | Researcher Profile | Sotabase | Sotabase