Sotabase

Career

· Doctor of Philosophy - PhD, Computer Science, Northeastern University2025–2025
· Bachelor of Science - BS, Mathematics and Computer Science, University of Maryland2021–2025
· AI ML Intern, Intelligent Automation, a BlueHalo Company2020–2024
· Summer Intern, Columbia University in the City of New York2019–2019

Publications (85)

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
Science · 2016
1,961
cited
Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems.
Molecules and Cells · 2015
1,100
cited
Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence
Proceedings of the National Academy of Sciences of the United States of America · 2011
705
cited
Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system
Nature Communications · 2012
554
cited
CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3.
Molecules and Cells · 2012
512
cited
Transcription, processing and function of CRISPR cassettes in Escherichia coli
Molecular Microbiology · 2010
238
cited
Genome-Wide Identification of Regulatory RNAs in the Human Pathogen Clostridium difficile
PLoS Genetics · 2013
220
cited
Type I-E CRISPR-Cas Systems Discriminate Target from Non-Target DNA through Base Pairing-Independent PAM Recognition
PLoS Genetics · 2013
217
cited
Low‐molecular‐weight post‐translationally modified microcins
Molecular Microbiology · 2007
136
cited
High-throughput analysis of type I-E CRISPR/Cas spacer acquisition in E. coli
RNA Biology · 2013
107
cited
Foreign DNA acquisition by the I-F CRISPR–Cas system requires all components of the interference machinery
Nucleic Acids Research · 2015
89
cited
An engineered 800 kilobase deletion of Uchl3 and Lmo7 on mouse chromosome 14 causes defects in viability, postnatal growth and degeneration of muscle and retina.
Human Molecular Genetics · 2003
87
cited
The antibacterial threaded-lasso peptide capistruin inhibits bacterial RNA polymerase.
Journal of Molecular Biology · 2011
82
cited
Highly efficient primed spacer acquisition from targets destroyed by the Escherichia coli type I-E CRISPR-Cas interfering complex
Proceedings of the National Academy of Sciences of the United States of America · 2016
81
cited
Analysis of CRISPR system function in plant pathogen Xanthomonas oryzae.
FEMS Microbiology Letters · 2009
78
cited
Ex-vivo gene therapy restores LEKTI activity and corrects the architecture of Netherton syndrome-derived skin grafts.
Molecular Therapy · 2011
77
cited
Kinetics of the CRISPR-Cas9 effector complex assembly and the role of 3′-terminal segment of guide RNA
Nucleic Acids Research · 2016
77
cited
Analysis of Promoter Targets for Escherichia coli Transcription Elongation Factor GreA In Vivo and In Vitro
Journal of Bacteriology · 2007
74
cited
The action of Escherichia coli CRISPR–Cas system on lytic bacteriophages with different lifestyles and development strategies
Nucleic Acids Research · 2017
73
cited
Function of the CRISPR-Cas System of the Human Pathogen Clostridium difficile
mBio · 2015
69
cited
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