Sotabase

Career

· Associate Professor, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF2008–
· Professor, UCSF2008–
· Neurosurgeon, UCSF Medical Center2008–
· Staff Neurosurgeon, VA Medical Center (Current)2008–
· Residency, Neurological Surgery, University of California, San Francisco2002–2008
· MD, Medicine, Cornell University1994–2002
· PhD, Neuroscience, Neural Stem Cells, The Rockefeller University1994–2000
· B.A., Biochemistry, MCB, University of California, Berkeley1990–1994

Publications (51)

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
Science · 2011
1,083
cited
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
Nature · 2008
725
cited
MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.
Molecules and Cells · 2005
447
cited
mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin
Science · 2013
429
cited
Structure and function of Polo-like kinases
Oncogene · 2005
320
cited
Proteomic screen defines the Polo‐box domain interactome and identifies Rock2 as a Plk1 substrate
EMBO Journal · 2007
249
cited
The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response
PLoS Pathogens · 2012
227
cited
Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling
Science Signaling · 2011
177
cited
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
Nature Structural &Molecular Biology · 2009
127
cited
ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest.
Cell Systems · 2019
112
cited
Activation of the Yeast Hippo Pathway by Phosphorylation-Dependent Assembly of Signaling Complexes
Science · 2013
108
cited
Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling.
International Journal of Parasitology · 2011
69
cited
Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using oxime-based diversification.
ACS Chemical Biology · 2012
63
cited
Drill Sergeant: Supporting Physical Construction Projects through an Ecosystem of Augmented Tools
CHI Extended Abstracts · 2016
56
cited
Tranexamic acid mediates proinflammatory and anti-inflammatory signaling via complement C5a regulation in a plasminogen activator–dependent manner
Journal of Trauma and Acute Care Surgery · 2019
52
cited
Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.
Bioorganic & Medicinal Chemistry · 2013
40
cited
Peptoid–Peptide Hybrid Ligands Targeting the Polo Box Domain of Polo‐Like Kinase 1
ChemBioChem · 2012
38
cited
Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division
Nature Communications · 2020
36
cited
Polo-Like Kinase-1 Controls Aurora A Destruction by Activating APC/C-Cdh1
PLoS ONE · 2009
35
cited
Structure of the Toxoplasma gondii ROP18 Kinase Domain Reveals a Second Ligand Binding Pocket Required for Acute Virulence*
Journal of Biological Chemistry · 2013
25
cited
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