Sotabase

Career

· J.D. Candidate, Columbia Law School2025–
· Director, UK Company (company number 12178668)2019–

Publications (59)

APOBEC3B is an enzymatic source of mutation in breast cancer
Nature · 2013
829
cited
Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B
Nature Structural &Molecular Biology · 2016
225
cited
APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.
Cancer Research · 2013
162
cited
The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis
Nature Communications · 2016
152
cited
Methylcytosine and Normal Cytosine Deamination by the Foreign DNA Restriction Enzyme APOBEC3A*
Journal of Biological Chemistry · 2012
127
cited
First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.
ACS Chemical Biology · 2012
120
cited
APOBEC3A catalyzes mutation and drives carcinogenesis in vivo
bioRxiv · 2019
118
cited
Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity
Nature Microbiology · 2018
115
cited
Crystal structure of the DNA cytosine deaminase APOBEC3F: the catalytically active and HIV-1 Vif-binding domain.
Structure · 2013
91
cited
The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.
Journal of Molecular Biology · 2013
89
cited
Determinants of sequence-specificity within human AID and APOBEC3G.
DNA Repair · 2010
88
cited
Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain*
Journal of Biological Chemistry · 2015
85
cited
Endogenous APOBEC3A DNA Cytosine Deaminase Is Cytoplasmic and Nongenotoxic*
Journal of Biological Chemistry · 2013
81
cited
APOBEC3 multimerization correlates with HIV-1 packaging and restriction activity in living cells.
Journal of Molecular Biology · 2014
68
cited
The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism.
Molecules and Cells · 2018
62
cited
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer
Nature Genetics · 2023
56
cited
A Rabbit Monoclonal Antibody against the Antiviral and Cancer Genomic DNA Mutating Enzyme APOBEC3B
bioRxiv · 2019
39
cited
Central base pair flipping and discrimination by PspGI
Nucleic Acids Research · 2008
37
cited
Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B
PLoS ONE · 2016
33
cited
Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B
eLife · 2020
31
cited
Sotabase
Alexandra Michael | Researcher Profile | Sotabase | Sotabase